02024cam a22003257a 4500020002500000020002200025082001700047100003000064245003500094250000800129260005800137300002300195500006200218500005500280500015400335500027800489505018800767520045500955650001701410650002601427650002901453650002801482650002701510650002501537650001401562650002001576650002001596654001301616856006901629  a9789241563499 (pbk.)  a9241563494 (pbk.)  a616.994bWHO  aWorld Health Organization10aIPCS mode of action framework   aNil  aGeneva, Switzerland bWorld Health Organizationc2007  aiv, 123 p. bill.   aCover title.: IPCS Harmonization Project Document (No. 4)  a"IPCS International Programme on Chemical Safety."  a"This project was conducted within the IPCS project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals"--P. [i].  a"Published under the joint sponsorship of the World Health Organization, the International Labour Organization and the United Nations Environment Programme, and produced within the framework of the Inter-Oganization Programme for the Sound Management of Chemicals"--P. [i].0 apt. 1. IPCS framework for analysing the relevance of a cancer mode of action for humans -- pt. 2. IPCS framework for analysing the relevance of a non-cancer mode of action for humans.  aThe use of structured frameworks in chemical risk assessment promotes transparent, harmonized approaches.  This publication presents two IPCS frameworks originally published in Critical reviews in toxicology.  The frameworks provide a means of ensuring a transparent evaluation of the data, identification of key data gaps and of information that would be of value in the further risk assessment of the chemical in question.--Publisher's description. 0aCarcinogens. 0aHazardous substances. 0aCarcinogenicity testing. 0aHealth risk assessment.22aCarcinogenicity Tests.22aHazardous Substances22aNeoplasms22aRisk Assessment22aRisk Management  aOncology41uhttp://whqlibdoc.who.int/publications/2007/9789241563499_eng.pdf